Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates

US7994143B2 · kind B2 · utility

Assignees

• CHIMERIX, INC. · US
• The Regents of the University of California · US

Inventors

• Karl Y. Hostetler · Del Mar, US
• James R. Beadle · Columbia, US
• Jacqueline Ruiz · San Diego, US
• Merrick R. Almond · Apex, US
• George R. Painter · Atlanta, US
• Timothy A. Riley · Alameda, US
• Paula Francom · Brea, US

Key dates

• Filing date: Jun 9, 2010
• Grant date: Aug 9, 2011
• Expiry date: Jun 9, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65616
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.