2-aminoquinoline derivatives

US7994324B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Sabine Kolczewski · Lörrach, DE
• Claus Riemer · Glückstadt, DE
• Olivier Roche · Folgensbourg, FR
• Lucinda Steward · Basel, CH
• Juergen Wichmann · Basel, CH
• Thomas Woltering · Freiburg (Elbe), DE

Key dates

• Filing date: Feb 27, 2009
• Grant date: Aug 9, 2011
• Expiry date: Apr 6, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is concerned with 2-aminoquinoline derivatives, in particular compounds of formula (I)wherein R1 and R2 are as described herein, pharmaceutical compositions containing such compounds, and methods for their manufacture. The compounds of the invention are 5-HT5A receptor antagonists useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.