Antibacterial quinoline derivatives

US7998979B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Jérôme Emile Georges Guillemont · Andé, FR
• Magali Madeleine Simone Motte · Louviers, FR
• Koenraad Jozef Lodewijk Marcel Andries · Beerse, BE
• Anil Koul · Edegem, BE

Key dates

• Filing date: Dec 4, 2007
• Grant date: Aug 16, 2011
• Expiry date: Aug 3, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or formula (Ib):including any stereochemically isomeric form thereof, a pharmaceutically acceptable salt thereof, a N-oxide form thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.