Biphenyl compounds useful in the treatment or prevention of cardiovascular disorders

US7998988B2 · kind B2 · utility

Assignee

• Bayer Schering Pharma AG · DE

Inventors

• Stephan Bartel · Bensberg, DE
• Michael Hahn · Langenfeld, DE
• Wahed Ahmed Moradi · Monheim, DE
• Klaus Münter · Mannheim, DE
• Thomas Rölle · Leverkusen, DE
• Johannes-Peter Stasch · Wuppertal, DE
• Karl-Heinz Schlemmer · Wuppertal, DE
• Frank Wunder · Wuppertal, DE

Key dates

• Filing date: Oct 9, 2006
• Grant date: Aug 16, 2011
• Expiry date: Jun 25, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D271/113
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to biphenyl compounds of formula (I):wherein U, V and W together form a group of the formula *—CH═CH—CH<, *—CH2—CH2—CH< or *—CH2—CH2—N<, in which * means the point of linkage to the phenyl ring; A is O or CH2; and D, E, X, Y, Z, R1, R2, o, n, and p are as defined in the specification. The invention also relates to pharmaceutical compositions of the compound of the compounds. The compounds and pharmaceutical compositions of the invention can be used in the treatment or prevention of cardiovascular disorders.