Methods of treating cancer using immunostimulatory oligonucleotides

US8008266B2 · kind B2 · utility

Assignees

• THE UNIVERSITY OF IOWA · US
• The United States of America, as represented by the Department of Health and Human Services · US
• COLEY PHARMACEUTICAL GMBH · DE

Inventors

• Arthur M. Krieg · Wellesley, US
• Alfred Steinberg · Potomac, US
• Dennis Klinman · Potomac, US

Key dates

• Filing date: Nov 21, 2003
• Grant date: Aug 30, 2011
• Expiry date: Nov 21, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.