Variants in complement regulatory genes predict age-related macular degeneration

US8012683B2 · kind B2 · utility

Assignees

• University of Iowa Research Foundation · US
• The Trustees of Columbia University in the City of New York · US
• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Rando Allikmets · Frederick, US
• Gregory S. Hageman · Coralville, US
• Michael Dean · Frederick, US
• Albert M. Gold · Frederick, US

Key dates

• Filing date: Feb 13, 2007
• Grant date: Sep 6, 2011
• Expiry date: Jul 4, 2028

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/164
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and kits for use in these methods are also provided.