Thrombin preparations and process for their production

US8012728B2 · kind B2 · utility

Assignee

• CSL Behring AG · DE

Inventors

• Hubert Metzner · Marburg, DE
• Heinrich Scheider · Lahntal, DE

Key dates

• Filing date: Mar 22, 2006
• Grant date: Sep 6, 2011
• Expiry date: Sep 12, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The production of a thrombin preparation which is obtained from prothrombin which is, after activation to thrombin without the addition of thromboplastin, purified by a hydrophobic interaction chromatography, it being possible subsequently also to inactivate or remove viruses, is described. Before or after the hydrophobic interaction chromatography it is also possible in addition to carry out a cation exchange chromatography. A thrombin preparation which contains as stabilizer a noncovalently binding inhibitor and to which further stabilizers can be added for stabilization in the liquid state is additionally described.