Tie-2 modulators and methods of use

US8013156B2 · kind B2 · utility

Assignee

• Exelixis, Inc. · US

Inventors

• Lynne Canne Bannen · Pacifica, US
• S. David Brown · Redwood City, US
• Wei Cheng · South San Francisco, US
• Vasu Jammalamadaka · Irvine, US
• John M. Nuss · Danville, US
• Morrison B. Mac · San Francisco, US
• Jason Jevious Parks · Sacramento, US
• Matthew A. Williams · Foster City, US
• Wei Xu · Saginaw, US
• Atwood Kim CHEUNG · Arlington, US
• Lisa Esther Dalrymple · Seattle, US
• Sergey Epshteyn · Fremont, US
• Mohamed Abdulkader Ibrahim · Mountain View, US
• James William Leahy · San Leandro, US
• Gary L. Lewis · San Francisco, US
• Robin Tammie Noguchi · San Bruno, US
• Larry W. Mann · Redwood City, US
• Brian Hugh Ridgway · Belmont, US
• Joan C. Sangalang · San Francisco, US
• Kevin Luke Schnepp · Elk Grove, US
• Xian Shi · San Bruno, US
• Richard George Khoury · Redwood City, US

Key dates

• Filing date: Mar 19, 2004
• Grant date: Sep 6, 2011
• Expiry date: Feb 28, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.