Methods for characterizing agonists and partial agonists of target molecules

US8014954B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Yejun Tan · Seattle, US
• Hongyue Dai · Bothell, US
• Pek Yee Lum · Palo Alto, US
• John R. Thompson · Onda, ES
• Joel Berger · Hoboken, US
• Eric Stanley Muise · New York, US
• Richard F. Raubertas · Saint Johnsbury Center, US
• Kenny Kin Chung Wong · Edison, US

Key dates

• Filing date: Apr 4, 2006
• Grant date: Sep 6, 2011
• Expiry date: May 7, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.