Spatially-defined macrocyclic compounds useful for drug discovery
US8022252B2 · kind B2 · utility
3Cited by
9References
3Claims
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Key dates
| Filing date | Aug 25, 2008 |
| Grant date | Sep 20, 2011 |
| Priority date | — |
| Expiry date | Aug 25, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0827
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.