Oligodeoxynucleotide and its use to induce an immune response

US8030285B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Dennis Klinman · Potomac, US
• Ken Ishii · Columbia, US
• Daniela Verthelyi · Potomac, US
• James Mond · Potomac, US

Key dates

• Filing date: Nov 9, 2006
• Grant date: Oct 4, 2011
• Expiry date: Dec 22, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2989
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a substantially pure or isolated oligodeoxynucleotide of at least about 10 nucleotides comprising a sequence represented by either the formula:5′N1N2N3T-CpG-WN4N5N63′wherein the central CpG motif is unmethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are any nucleotides, or the formula:5′RY-CpG-RY3′wherein the central CpG motif is unmethylated, R is. A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host.