Patent · US Active

5′-modified bicyclic nucleic acid analogs

US8030467B2 · kind B2 · utility

118Cited by

134References

26Claims

0Family size

Assignee

Isis Pharmaceuticals, Inc. · US

Inventors

Punit P. Seth · Carlsbad, US
Eric E. Swayze · Carlsbad, US
Balkrishen Bhat · Carlsbad, US

Key dates

Filing date	Mar 31, 2010
Grant date	Oct 4, 2011
Priority date	—
Expiry date	Mar 31, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H21/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5′-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.