Antidiabetic bicyclic compounds

US8039484B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Min Ge · Nanjing, CN
• Songnian Lin · Sparta, US
• Shawn P. Walsh · Bound Brook, US
• Lihu Yang · Edison, US
• Changyou Zhou · Princeton, US

Key dates

• Filing date: Oct 26, 2007
• Grant date: Oct 18, 2011
• Expiry date: Aug 31, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Diaryl ethers in which one of the aryl groups is a phenyl fused to a cycloalkyl or heterocyclic ring, to which is attached an acetic acid group, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that often accompany this disease, including insulin resistance, obesity and lipid disorders.