Biaryl sulfonamide derivatives

US8039493B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Henrietta Dehmlow · Weil am Rhein, DE
• Ulrike Obst Sander · Sursee, CH
• Tanja Schulz-Gasch · Ziefen, CH
• Matthew Wright · Basel, CH

Key dates

• Filing date: Sep 17, 2008
• Grant date: Oct 18, 2011
• Expiry date: May 17, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is concerned with novel biaryl sulfonamide derivatives of formula (I)wherein R1 to R3 and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.