Patent · US Active

Process for preparing (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino) ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol

US8039628B2 · kind B2 · utility

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Assignee

Janssen Pharmaceutica NA · BE

Inventors

Frank Porstmann · Spreitenbach, CH
Stefan Horns · Schaffhausen, CH
Thomas Bader · Zürich, CH

Key dates

Filing date	May 22, 2006
Grant date	Oct 18, 2011
Priority date	—
Expiry date	Jan 7, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F9/65744
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a process for isolating (αS,βR)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.