Conformationally stabilized HIV envelope immunogens and triggering HIV-I envelope to reveal cryptic V3-loop epitopes

US8044185B2 · kind B2 · utility

Assignees

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US
• DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

• Peter Kwong · Washington, US
• John Mascola · Rockville, US
• Gary J. Nabel · Cambridge, US
• Richard Wyatt · Village of La Jolla, US
• Barna Dey · Germantown, US
• Ling Xu · Potomac, US
• Tongqing Zhou · Boyds, US
• Chih-Chin Huang · Sylvania, US
• Joseph Sodroski · Medford, US
• Wen Yuan · Watertown, US
• Shi-Hua Xiang · Boston, US

Key dates

• Filing date: Sep 6, 2006
• Grant date: Oct 25, 2011
• Expiry date: Aug 4, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including atomic coordinates for stabilized forms of gp120, and gp120 with an extended V3 loop, and methods of using these structures and computer systems are also disclosed.