Micropatterning of biological molecules using laser ablation

US8048641B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Andrew Doyle · Hyattsville, US
• Kenneth M. Yamada · Bethesda, US
• Francis W. Wang · Gaithersburg, US

Key dates

• Filing date: Oct 10, 2008
• Grant date: Nov 1, 2011
• Expiry date: May 19, 2030

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B29K2995/0092
• WIPO field: Other special machines
• WIPO sector: Mechanical engineering

Abstract

The present invention employs the natural hydrophilic properties of a macromolecular film such as a hydrogel and in combination with localized photo-ablation of monolayers created with the hydrogel using multi-photon laser excitation, provides a stampless, versatile method of micropattern fabrication.