Methods and compositions concerning siRNA's as mediators of RNA interference
US8058255B2 · kind B2 · utility
15Cited by
60References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 15, 2009 |
| Grant date | Nov 15, 2011 |
| Priority date | — |
| Expiry date | Jun 15, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2330/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention concerns an isolated siRNA of from about 5 to about 20 nucleotides that mediates RNA interference. Also disclosed are methods of reducing expression of a target gene in a cell comprising obtaining at least one siRNA of 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 basepairs in length; and delivering the siRNA into the cell. The siRNAs can be chemically synthesized RNA or an analog of a naturally occurring RNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.