Selective inhibitors of rock protein kinase and uses thereof

US8058271B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Jeremy Green · Waltham, US
• Jingrong Cao · Newton, US
• Upul K. Bandarage · Lexington, US
• Jon Come · Cambridge, US
• Craig Marhefka · Belmont, US

Key dates

• Filing date: May 10, 2007
• Grant date: Nov 15, 2011
• Expiry date: Sep 8, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are compounds that are useful as ROCK inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including cardiovascular, inflammatory, neurological, or proliferative diseases or disorders.