Solid forms of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine

US8063076B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Thomas Cleary · Mendocino, US
• Alexander Glomme · Birsfelden, CH
• Olaf Grassmann · Soest, DE
• Shan-Ming Kuang · Florence, US
• Roland Meier · Ueken, CH
• Doreen Miller · Florence, US
• Regina Moog · Glückstadt, DE
• Franziska E. Rohrer · Riehen, CH
• Jason Yang · Florence, US

Key dates

• Filing date: Dec 17, 2007
• Grant date: Nov 22, 2011
• Expiry date: Aug 12, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the mono-sulfate salt, crystalline forms A and B of the mono-sulfate salt, an amorphous form of the mono-sulfate salt, hemi-sulfate salts, and a crystalline form A of the hemi-sulfate salt of the compound 2-chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine.