Methods and compositions for inhibiting CD32B expressing cells

US8063187B2 · kind B2 · utility

Assignee

• Xencor, Inc. · US

Inventors

• Seung Chu · Cypress, US
• John Desjarlais · Pasadena, US
• Sher Bahadur Karki · Pasadena, US
• Gregory Alan Lazar · Los Angeles, US
• Gregory Moore · Monrovia, US
• Igor Vostiar · Monrovia, US

Key dates

• Filing date: May 30, 2008
• Grant date: Nov 22, 2011
• Expiry date: May 11, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.