Isolated nucleic acid molecule encoding a peptide or peptide analog comprising the SEQ ID No. 3

US8071746B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Alan T. Remaley · Bethesda, US
• Stephen J. Demosky · Gaithersburg, US
• John A. Stonik · Gaithersburg, US
• Marcele J. A. Amar · Gaithersburg, US
• Edward B. Neufeld · Washington, US
• Bryan Brewer · Potomac, US
• Fairwell Thomas · Rockville, US

Key dates

• Filing date: Jul 2, 2009
• Grant date: Dec 6, 2011
• Expiry date: Jul 2, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.