Alkylquinoline and alkylquinazoline kinase modulators
US8071768B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 6, 2006 |
| Grant date | Dec 6, 2011 |
| Priority date | — |
| Expiry date | May 6, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula I:wherein R1, R2, R3, B, Z, G, Q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or c-kit and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or c-kit and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or c-kit and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.