Patent · US Active

Compositions and methods for inhibiting expression of Huntingtin gene

US8080532B2 · kind B2 · utility

1Cited by

2References

24Claims

0Family size

Assignee

Alnylam Pharmaceuticals, Inc. · US

Inventors

Dinah Wen-Yee Sah · Boston, US
Philipp Hadwiger · Kulmbach, DE
Ingo Roehl · Memmelsdorf, DE
Birgit Bramlage · Ebikon, CH
Pamela Tan · Kulmbach, DE
Hans-Peter Vornlocher · Bayreuth, DE
David Bumcrot · Belmont, US

Key dates

Filing date	Apr 2, 2009
Grant date	Dec 20, 2011
Priority date	—
Expiry date	Sep 30, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/321
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Huntingtin gene (HD gene), comprising an antisense strand having a nucleotide sequence which is less than 25 nucleotides in length and which is substantially complementary to at least a part of the HD gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the HD gene, or a mutant form thereof, using the pharmaceutical composition; and methods for inhibiting the expression of the huntingtin gene in a cell.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.