Methods for treating hypercholesterolemia

US8084437B2 · kind B2 · utility

Assignee

• Isis Pharmaceuticals, Inc. · US

Inventors

• Susan M. Freier · San Diego, US
• Rosanne M. Crooke · Carlsbad, US
• Mark J. Graham · San Clemente, US
• Kristina M. Lemonidis · Temecula, US
• Sanjay Bhanot · Carlsbad, US
• Diane Tribble · Carlsbad, US
• Andrew Watt · San Diego, US

Key dates

• Filing date: Nov 27, 2007
• Grant date: Dec 27, 2011
• Expiry date: Nov 27, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/346
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating hypercholesterolemia, or alternatively for treating or preventing atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.