Patent · US Active

Bis-modified bicyclic nucleic acid analogs

US8088746B2 · kind B2 · utility

105Cited by

134References

26Claims

0Family size

Assignee

Isis Pharmaceuticals, Inc. · US

Inventors

Punit P. Seth · Carlsbad, US
Eric E. Swayze · Carlsbad, US

Key dates

Filing date	Jan 14, 2010
Grant date	Jan 3, 2012
Priority date	—
Expiry date	Jan 31, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H23/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present disclosure describes bis-modified bicyclic nucleosides and oligomeric compounds that can be prepared comprising at least one of these bis-modified bicyclic nucleosides. More particularly, the bis-modified bicyclic nucleosides have at least one substituent group at the 5′-methylene and on the bridge methylene and can be chiral. These bis-modified bicyclic nucleosides are expected to be useful for enhancing one or more property of oligomeric compounds including for example enhancing nuclease resistance.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.