JAK-2 modulators and methods of use

US8088767B2 · kind B2 · utility

Assignee

• Exelixis, Inc. · US

Inventors

• Adam Galan · Alameda, US
• Jeff Chen · San Francisco, US
• Hongwang Du · Millbrae, US
• Timothy Patrick Forsyth · Hayward, US
• Tai Phat Huynh · Oakland, US
• Henry Johnson · San Bruno, US
• Patrick Kearney · San Francisco, US
• James William Leahy · San Leandro, US
• Matthew Sangyup Lee · San Francisco, US
• Grace Mann · Brisbane, US
• Brian Hugh Ridgway · Belmont, US
• Craig Stacy Takeuchi · Burlingame, US
• Peiwen Zhou · Palo Alto, US

Key dates

• Filing date: Sep 28, 2007
• Grant date: Jan 3, 2012
• Expiry date: Sep 28, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.