Targeting the histone code as a bacterial strategy for selectively modulating gene expression
US8092989B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 15, 2006 |
| Grant date | Jan 10, 2012 |
| Priority date | — |
| Expiry date | Mar 10, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins include MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, and BCL2 related proteins. Methods for treating diseases using OspF phosphatase, methods for identifying agents that modulate OspF phosphatase's activity, methods for identifying agents that mimic OspF phosphatase's activity, and immunogenic compositions comprising OspF phosphatase are provided. A strain of Shigella flexneri containing an inactivated ospF gene is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.