Methods for treating hypercholesterolemia

US8093222B2 · kind B2 · utility

Assignee

• Isis Pharmaceuticals, Inc. · US

Inventors

• Susan M. Freier · San Diego, US
• Rosanne M. Crooke · Carlsbad, US
• Mark J. Graham · San Clemente, US
• Kristina L. Lemonidis · Carlsbad, US
• Sanjay Bhanot · Carlsbad, US
• Diane Tribble · Carlsbad, US
• Andrew Watt · San Diego, US

Key dates

• Filing date: Jun 4, 2009
• Grant date: Jan 10, 2012
• Expiry date: Jun 4, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.