Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors
US8097637B2 · kind B2 · utility
1Cited by
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15Claims
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Key dates
| Filing date | Aug 1, 2008 |
| Grant date | Jan 17, 2012 |
| Priority date | — |
| Expiry date | May 16, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compounds of formula (I)wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D3 and serotonin (5-Hydroxytryptamine; 5-HT) 5-HT2A receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.