Compositions and methods related to TIM-3, a TH1-specific cell surface molecule
US8101176B2 · kind B2 · utility
31Cited by
3References
20Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Nov 24, 2008 |
| Grant date | Jan 24, 2012 |
| Priority date | — |
| Expiry date | Jan 11, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.