Benzylbenzene derivatives and methods of use

US8106021B2 · kind B2 · utility

Assignee

• Theracos, Inc. · US

Inventors

• Yuanwei Chen · Sichuan, CN
• Huawei Cheng · Shanghai, CN
• Shengbin Li · Shanghai, CN
• Yuelin Wu · Beijing, CN
• Yan Feng · Chengdu, CN
• Binhua Lv · 安丰镇, CN
• Baihua Xu · Shanghai, CN
• Brian Seed · Boston, US
• Michael J. Hadd · San Diego, US
• Yanli Song · Shanghai, CN
• Jiyan Du · Shanghai, CN
• Congna Wang · Pudong New District, CN
• Jacques Y. Roberge · Princeton, US

Key dates

• Filing date: Nov 1, 2010
• Grant date: Jan 31, 2012
• Expiry date: Nov 1, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D407/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.