Dual-acting antihypertensive agents
US8106082B2 · kind B2 · utility
2Cited by
21References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 6, 2010 |
| Grant date | Jan 31, 2012 |
| Priority date | — |
| Expiry date | Oct 6, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to compounds having the formula:wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.