3-carboxypropyl-aminotetralin derivatives and related compounds as mu opioid receptor antagonists
US8106232B2 · kind B2 · utility
4Cited by
3References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 10, 2008 |
| Grant date | Jan 31, 2012 |
| Priority date | — |
| Expiry date | Apr 19, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/173845
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I):wherein R1, R2, R3, R4, R5, and R6 are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.