Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto
US8110187B2 · kind B2 · utility
4Cited by
11References
5Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 8, 2002 |
| Grant date | Feb 7, 2012 |
| Priority date | — |
| Expiry date | Aug 3, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/806
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is a novel cytokine protein called IL-12 or Cytotoxic Lymphocyte Maturation Factor (CLMF) which is produced and synthesized by human NC-37 B lymphoblastoid cells (American Type Culture Collection, Rockville, Md.). CLMF synergistically induces with low concentrations of IL-2 the cytolytic activity of Lymphokine Activated Killer (LAK) cells, and CLMF is capable of stimulating T-cell growth.Also claimed are the cloned gene for CLMF, its recombination in a suitable vector, the transformed cells containing said vector, the recombinant protein produced by the transformed cells and antibodies to CLMF.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.