Expanding the eukaryotic genetic code
US8114628B2 · kind B2 · utility
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11References
12Claims
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Key dates
| Filing date | Oct 26, 2007 |
| Grant date | Feb 14, 2012 |
| Priority date | — |
| Expiry date | Oct 26, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/975
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.