Dual-acting pyrazole antihypertensive agents
US8119634B2 · kind B2 · utility
5Cited by
25References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 4, 2011 |
| Grant date | Feb 21, 2012 |
| Priority date | — |
| Expiry date | Jan 4, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In one aspect, the invention relates to compounds having the formula:wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.