Hydroxymethyl ether hydroisoindoline tachykinin receptor antagonists
US8124633B2 · kind B2 · utility
16Cited by
6References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 7, 2008 |
| Grant date | Feb 28, 2012 |
| Priority date | — |
| Expiry date | Dec 29, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, LUTS, depression, and anxiety.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.