Immunostimulatory nucleic acid molecules

US8129351B2 · kind B2 · utility

Assignees

• University of Iowa Research Foundation · US
• COLEY PHARMACEUTICAL GMBH · DE
• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Arthur M. Krieg · Wellesley, US
• Dennis Klinman · Potomac, US
• Alfred Steinberg · Potomac, US

Key dates

• Filing date: Feb 25, 2005
• Grant date: Mar 6, 2012
• Expiry date: Sep 30, 2027

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.