Oligomeric compounds and compositions for the use in modulation of microRNAs
US8129515B2 · kind B2 · utility
57Cited by
128References
27Claims
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Key dates
| Filing date | Jan 27, 2007 |
| Grant date | Mar 6, 2012 |
| Priority date | — |
| Expiry date | Nov 24, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA activity in a cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.