Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases

US8138193B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Martin James Inglis Andrews · Mechelen, BE
• Mark Stuart Chambers · Watford, GB
• Wolfgang Schmidt · Frankfurt, DE
• Gregory Bar · Mechelen, BE

Key dates

• Filing date: Apr 2, 2010
• Grant date: Mar 20, 2012
• Expiry date: Apr 2, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P29/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel fused pyrazine compounds are disclosed that have a formula represented by the following:with Z, R1, R2, R8 and R9 as defined in the written description. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.