Patent · US Active

Purification of pegylated polypeptides

US8138317B2 · kind B2 · utility

2Cited by

27References

16Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Josef Burg · Weilheim, DE
Klaus Reichert · Oberhausen, DE
Axel Schroth · Sindelsdorf, DE
Hartmut Schurig · Munich, DE
Axel Wessner · Penzberg, DE

Key dates

Filing date	Jul 16, 2008
Grant date	Mar 20, 2012
Priority date	—
Expiry date	Oct 17, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K14/505
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention is a method for the purification of mono-PEGylated erythropoietin using two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.