Compositions and methods for mediating RNAi in vivo
US8148344B2 · kind B2 · utility
2Cited by
67References
25Claims
0Family size
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Key dates
| Filing date | Mar 26, 2009 |
| Grant date | Apr 3, 2012 |
| Priority date | — |
| Expiry date | May 27, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to new formulated lipid particles (FLiPs) comprising at least one of a single or double stranded oligonucleotide, where the oligonucleotide has been conjugated to a lipophile and at least one of an emulsion or liposome to which the conjugated oligonucleotide has been aggregated, admixed or associated. These particles have surprisingly been shown to effectively deliver oligonucleotides to heart, lung and muscle where they effect gene silencing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.