Patent · US Active

2,4 (4,6) pyrimidine derivatives

US8148388B2 · kind B2 · utility

6Cited by

1References

31Claims

0Family size

Assignee

Janssen Pharmaceutica NA · BE

Inventors

Eddy Jean Edgard Freyne · Rumst, BE
Marc Willems · Beerse, BE
Werner Constant Johan Embrechts · Beerse, BE
Kristof Van Emelen · Sint-Niklaas, BE
Sven Franciscus Anna Van Brandt · Nijlen, BE
Frederik Jan Rita Rombouts · Wilrijk, BE

Key dates

Filing date	Dec 8, 2005
Grant date	Apr 3, 2012
Priority date	—
Expiry date	Jan 31, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D498/18
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention is drawn to 2,4 (4,6) pyrimidine derived macrocyclcs, pharmaceutical compositions thereof, and methods of making said compounds. The compounds disclosed herein are inhibitors of EGF receptor tyrosine kinases and are useful for treating cell proliferative disorders, including atherosclerosis, restenosis, and cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.