Calicheamicin derivative-carrier conjugates

US8153768B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Arthur Kunz · Pocatello, US
• Justin Keith Moran · Valley Cottage, US
• Joseph Thomas Rubino · Towaco, US
• Neera Jain · New City, US
• Eugene Joseph Vidunas · Middletown, US
• John McLean Simpson · Upper Nyack, US
• Paul D. Robbins · Upper Nyack, US
• Nishith Merchant · Palisades Park, US
• John Francis DiJoseph · Woodbridge, US
• Mark Edward Ruppen · Garnerville, US
• Nitin K. Damle · Upper Saddle River, US
• Andrew George Popplewell · Grafton, GB

Key dates

• Filing date: May 2, 2003
• Grant date: Apr 10, 2012
• Expiry date: Nov 13, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.