MTP inhibiting tetrahydro-naphthalene-1-carboxylic acid derivatives
US8158783B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Oct 22, 2007 |
| Grant date | Apr 17, 2012 |
| Priority date | — |
| Expiry date | May 15, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is concerned with novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes. Formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.