Pyrimidine compounds, compositions and methods of use

US8163763B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Philippe Bergeron · San Francisco, US
• Frederick Cohen · San Francisco, US
• Anthony Estrada · Redwood City, US
• Michael F. T. Koehler · Palo Alto, US
• Kevin Hon Luen Lau · San Mateo, US
• Cuong Ly · Burlingame, US
• Joseph P. Lyssikatos · South San Francisco, US
• Daniel Fred Ortwine · San Ramon, US
• Zhonghua Pei · South San Francisco, US
• Xianrui Zhao · South San Francisco, US

Key dates

• Filing date: Jul 31, 2009
• Grant date: Apr 24, 2012
• Expiry date: Jul 25, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).