Method for making a 21 nucleotide double stranded RNA chemically linked at one end

US8168776B2 · kind B2 · utility

Assignee

• Alnylam Pharmaceuticals, Inc. · US

Inventors

• Roland Kreutzer · Weidenberg, DE
• Stefan Limmer · Neudrossenfeld, DE

Key dates

• Filing date: Mar 6, 2003
• Grant date: May 1, 2012
• Expiry date: Sep 6, 2024

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods and compositions for inhibiting gene expression using double stranded RNA molecules that are between 15 and 21 nucleotides in length and are complementary to a target gene sequence.