Mammalian sweet taste receptors

US8198048B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Charles S. Zuker · San Diego, US
• Nicholas J. P. Ryba · Bethesda, US
• Gregory A. Nelson · San Diego, US
• Mark Hoon · Kensington, US
• Jayaram Chandrashekar · San Diego, US
• Yifeng Zhang · Boston, US

Key dates

• Filing date: Mar 10, 2010
• Grant date: Jun 12, 2012
• Expiry date: May 29, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/705
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.