Patent · US Active

3-arylamino pyridine derivatives

US8198457B2 · kind B2 · utility

7Cited by

2References

12Claims

0Family size

Assignee

MERCK SERONO SA · CH

Inventors

Ulrich Abel · Schifferstadt, DE
Holger Deppe · Heidelberg, DE
Achim Feurer · Wilhelmsfeld, DE
Ulrich Grädler · Heidelberg, DE
Kerstin Otte · Heidelberg, DE
Renate Sekul · Ladenburg, DE
Meinolf Thiemann · Schriesheim, DE
Andreas Goutopoulos · Boston, US
Matthias Schwarz · Gland, CH
Xuliang Jiang · Braintree, US

Key dates

Filing date	May 20, 2011
Grant date	Jun 12, 2012
Priority date	—
Expiry date	May 20, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D401/12
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention provides novel, substituted 3-arylamino pyridine compoundspharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.